Charlotte Le Bon is a multidisciplinary artist who shines both in Quebec and internationally. She makes a remarkable television debut when she brings her unique touch of comedy to the Grand Journal (Canal +) in 2010. Her role as Claire in La Marche by Nabil Ben Yadir earns her a nomination at the prestigious Césars for Revelation of the Year in 2013. In 2014, she is the very endearing character of Anna in Benjamin Guedj's Libre et Assoupi. Charlotte offers a remarkable performance in Yves Saint Laurent by Jail Lespert where she takes on the role of Victoire Doutreleau. The part earns her her second Césars nomination for Best Supporting Actress. She then began a career in the United States, working with directors such as Lars Hallström, Robert Zemeckis and Sean Ellis.

She defends one of the two lead roles in the beautiful series Cheyenne and Lola in 2020 and charms the public in C'est comme ça que je t'aime, directed by Jean-François Rivard and Robin Aubertin 2022. 

Also a visual artist, Charlotte explores the strange through painting, drawing and lithography. A fan of genre cinema, she wrote and directed her first short film Judith Hôtel, presented at Cannes in 2018.

In 2022, she wrote and directed her first feature film, Falcon Lake. The film was selected for the Director's Fortnight as part of the 75th Cannes Film Festival. Upon its release, Falcon Lake enjoyed critical success and won several awards, including the Louis-Delluc Prize, the John Dunning Prize as well as a Césars nomination for Best first film.

She leads the film Niki, a biopic on the french artist Niki de Saint Phalle, directed by Céline Sallette.